John Fung, MD, PhD
Professor of Surgery
Chief, Section of Transplant Surgery
Co-Director, Transplant Institute
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Angelica Perez Gutierrez, MD, is a highly skilled surgeon who specializes in transplant surgery. Dr. Perez’s areas of expertise include pancreatic islet transplant, liver transplant and kidney transplant.
Balancing the Scale:
Dr. R. Angelica Perez Gutierrez Works to Expand the Donor Pool and Improve the Quality of Life for Transplant Patients
Growing up in Mexico, Dr. Perez was influenced by her father and mother in equal measure. Her father was a university professor who instilled in her the importance of a rigorous education. While her mother was a dedicated homemaker and philanthropically minded. There’s little doubt being brought up in this environment invigorated her aspiration to pursue a career in surgery.
R. Angelica Perez Gutierrez, MD
Clinical Associate of Surgery
The journey to the operating room is not a feat for the faint of heart. Dr. Perez was up for the challenge to feed her incessant excitement in becoming a pioneer in the field of modern medicine.
“I always felt super excited about surgery,” said Dr. Perez. Initially, she went back and forth between cardiothoracic and vascular surgery; however, in transplant she found her true calling. “What I like about transplant is that you have so many specialties together. I also like that it includes complex vascular surgery, and the significant impact on the quality of life of the patients is almost instant,” she said.
For Dr. Perez, being in the right place at the right moment allowed her to meet fellow surgical leaders who enabled her to seize opportunities that would eventually launch her career toward where it is today. By way of serendipity, she met mentors like Chief of the Section of Transplant Surgery and Co-Director of the University of Chicago Medicine Transplant Institute John Fung, MD, who supported her and encouraged her move to the United States, where she would undoubtedly find a rich foundation for her impactful research to blossom.
Dr. Perez can be seen here holding DeBakey pickups, which are commonly used for compressing or grasping tissues during transplant operations.
Increasing case volumes
UChicago Medicine already has a long history of achievements in organ transplantation, from developing the technique for joining severed ends of blood vessels together to performing the first living donor liver transplant in the U.S. In 2018, the transplant team made history again when they performed two back-to-back triple heart-liver-kidney transplants. Multiple organ transplants are rare and require equal parts medical excellence, surgical skill, complex coordination and creativity.
“I remember when I was a fellow, we were doing maybe two or three liver transplants per month. Now we’re doing about one or two liver transplants per week. We have been growing every year. I think it’s great that the transplant program has improved significantly, and I have had the opportunity to see this growth firsthand.”
The program’s continuous growth has provided Dr. Perez with the opportunity to lead a multitude of cases. Even if she isn’t in service, she often situates herself in the OR by providing support or scrubbing in when needed. UChicago Medicine’s transplant team encompasses an accomplished group of team players who work collaboratively to thoughtfully treat the needs of each patient. As the program continues to grow, the quality of life of transplant patients will, without question, improve.
Every year in the U.S., many people with liver failure expire waiting for a transplant, as the need for donor organs is far greater than the number of living donors obtainable for transplantation. “Here in Chicago, and more specifically here at the University of Chicago, we don’t have so many living donors,” said Dr. Perez. “We have been trying to increase awareness in living donation. Although we have been doing more living donor liver and kidney transplants, it’s still a small number, which opens up more opportunities.”
While the numbers of living donors may be lower, UChicago Medicine has been a pioneer in the field of living donor transplant surgery. In 1989, our surgical team performed the first successful living donor liver transplant, where a parent gave part of her liver to her daughter. Despite the disparaging deficit, the miraculous functionality of the human body saves the lives of countless patients.
So how is living donor organ donation possible? Because of the liver’s astounding capability to regenerate, living liver donors can give part of their healthy liver to a transplant patient. Living donors can also donate one of their two healthy kidneys to a patient, while still living a healthy life with just one. The other great news about this type of transplantation is how it affects the patients. Organs from living donors generally last longer with fewer complications and work better than those from deceased donors. As a group effort, Dr. Perez and her team are trying to push to have more organs from living donors, as successful outcomes will continue to ensue.
The dearth of donor organs combined with the upsurge in wait-listed patients has increased the usage of organs from expanded criteria donors and donors after circulatory death (DCD). Because of the poor outcomes these marginal organs have, there has been an increased concentration on vigorous preservation techniques, such as ex vivo machine perfusion to improve outcomes. “We do it as standard of care for the kidneys from DCD donors,” said Dr. Perez.
In 2018, approximately 50 percent of wait-listed patients did not receive an organ transplant and either remained wait-listed, became unfit for transplant or died while being wait-listed. This morbid statistic emphasizes the urgent need to tackle organ shortage. Researchers, including Dr. Perez and Dr. Fung, are working on one solution to address this problem: improving suboptimal organs by using machine perfusion as a preservation technique.
Machine perfusion involves reconditioning and repairing organs by restoring the blood flow of the donor organ by connecting it to a pump that adds oxygen and other preservation agents. “I’m very happy to be a part of Dr. Fung’s perfusion team,” said Dr. Perez. “It makes me very excited. As time goes on, there is more and more data that shows promising results with livers after hypothermic perfusion.”
UChicago Medicine’s Transplant Institute is committed to bridging gaps and disparities within the healthcare system when it comes to transplantation. Time is of the essence for these patients. Our group of dedicated researchers works tirelessly to discover treatment options that can save and improve quality of life.
Better outcomes ahead
When Dr. Perez was a fellow, she started a database of kidney transplant patients to chart specific outcomes and factors that can be modified. “Specifically, in our population, which is different from the national demographics which also include extremely high-risk patients,” she said. She collaborates with colleagues at UChicago Medicine to propel her research forward as she uncovers ways to improve outcomes.
R. Angelica Perez Gutierrez, MD
Clinical Associate of Surgery
She’s also had the opportunity to work in the lab of world-renowned research professor Anita S. Chong, PhD, on the outcomes of perfusion-assisted grafts.
Dr. Perez is a highly skilled surgeon who is enthusiastic about every facet of transplant surgery. Although she joined the Department of Surgery little more than a year ago, her impactful research and exceptional patient care are deeply admired by her peers and mentors. “The first kidney transplant I did alone was with Yolanda Becker, MD; she was very supportive to my career,” said Dr. Perez. “She knew just when it was the right moment to let go; she trusted me to get the job done.”
Dr. Perez prizes the mentorship she’s received here. Moreover, she deems it essential to be surrounded by leaders in the field who are invested in training and development. “I am also happy to work with the new members of the transplant team, like Professor of Surgery Rolf Barth, MD, who has been very supportive of me and my career development,” she said.
Passion over matter
Transplant is a rigorous specialty, with intricate life-or-death scenarios. Patients are severely ill and the stakes are high. They are usually in an unfavorable state of vulnerability, and surgery could completely alter the condition of their lives. “It’s tough; it has an emotional and physical burden,” said Dr. Perez. “I think you will succeed only if you really truly love it and you cannot imagine yourself doing anything else.”
Things are often in flux, but Dr. Perez’s outlook on the evolving state of transplant surgery is bright. The spark that ignites her drive is fueled by passion. “If you find passion in what you do then you’re never going to be tired,” she said. “Well, you will be tired, but then you won’t care. I think that is the way you can survive; love what you do in all senses.”
Professor of Surgery
Rolf Barth, MD, Professor of Surgery; Director, Liver, Kidney, and Pancreas Transplantation; Associate Director, Transplant Institute
Anita S. Chong, PhD, Professor of Surgery; Committee on Molecular Metabolism and Nutrition
John Fung, MD, PhD, Professor of Surgery; Chief, Section of Transplant Surgery; Co-Director, Transplant Institute
Associate Professor of Surgery
John LaMattina, MD, Associate Professor of Surgery
Piotr Witkowski, MD, PhD, Associate Professor of Surgery; Director, Pancreatic Islet Transplant and Abdominal Transplant Fellowship Programs
Assistant Professor of Surgery
Diego di Sabato, MD, Assistant Professor of Surgery; Co-Director, Living Donor Liver Transplant Program
Clinical Associate of Surgery
R. Angelica Perez Gutierrez, MD, Clinical Associate of Surgery
Research Associate Professor of Surgery
Dengping Yin, MD, PhD, Research Associate Professor of Surgery; Director, Animal Microsurgery Center
Anita S. Chong, PhD, was selected to receive the Francis Straus Mentorship Award. She was nominated by a mentee, and selected by the Faculty Advisory Committee and the Dean to be honored with this award.
John LaMattina, MD, and John Fung, MD, PhD, performed a successful liver transplant.
“Words cannot express how thankful we all are with the heroic job you have all done for my brother with his liver transplant. From the moment we walked into the Emergency Room at UChicago Medicine we were overwhelmed with extraordinary care and encountered highly talented nurses, doctors, surgeons and medical staff. I have never seen so many doctors and nurses and staff involved in my brother’s liver transplant. You guys never left us alone in this journey. You always explained everything to us, step by step, you empathized with us. I will forever have you all in my prayers. What you all do is absolutely amazing, heroic and beautiful. You give people like my brother a second chance to live. Thank you from the bottom of our hearts for all your wonderful work and care! Thank you to ALL!❤️”
R. Angelica Perez Gutierrez, MD, performed her first independent kidney transplant as an attending in January 2021.
John Fung, MD, PhD
Kose E, Kahramangil B, Aydin H, Donmez M, Aucejo F, Quintini C, Fung J, Berber E.: Minimally invasive resection of posterosuperior liver tumors in the supine position using intra-abdominal trocars. Surg Endosc. 2020 Feb;34(2):536-543.
Prachand VN, Milner R, Angelos P, Posner MC, Fung JJ, Agrawal N, Jeevanandam V, Matthews JB: Medically necessary, time-sensitive procedures: A scoring system to ethically and efficiently manage resource scarcity and provider risk during the COVID-19 pandemic. J Am Coll Surg. 2020 Apr 9. pii: S1072-7515(20)30317-3. doi: 10.1016/j.jamcollsurg.2020.04.011.
Bachul PJ, Gołębiewska JE, Basto L, Gołąb K, Anteby R, Wang LJ, Tibudan M, Thomas C, Fendler W, Lucander A, Grybowski DJ, Dębska-Ślizień A, Fung J, Witkowski P: BETA-2 scores is an early predictor of graft decline and loss of insulin independence after pancreatic islet allotransplantation. Am J Transplant. 2020 Mar;20(3):844-851. doi: 10.1111/ajt.15645. Epub 2019 Nov 13.
Generette GS, Bachul PJ, Golab K, Basto L, Pyda JS, Borek P, Tibudan M, Anteby R, Perea L, Charlton M, Perez-Gutierrez A, Jayant K, Lucander A, Matthews JB, Millis JM, Fung J, Witkowski P.: En bloc liver and pancreas transplantation after total pancreatectomy with autologous islet transplantation. Eur J Transl Clin Med. 2020;3(2):11-17. doi: 10.31373/ejtcm/130187. Epub 2020 Nov 23.
Bachul PJ, Grybowski DJ, Anteby R, Basto L, Perea L, Golab K, Wang LJ, Tibudan M, Perez-Gutierrez A, Komorniczak M, Nagpal S, Lucander A, Fung J, Matthews JB, Witkowski P.: Total pancreatectomy with islet autotransplantation in diabetic and pre-diabetic patients with intractable chronic pancreatitis. J Pancreatol. 2020 Jun;3(2):86-92. doi: 10.1097/jp9.0000000000000048.
Golab K, Krzystyniak A, Langa P, Pikuła M, Kunovac S, Borek P, Trzonkowski P, Millis JM, Fung J, Witkowski P.: Effect of serum on SmartFlare™ RNA Probes uptake and detection in cultured human cells. Biomed J Sci Tech Res. 2020;28(4):21788-21793. Epub 2020 Jul 2.
Prachand VN, Milner R, Angelos P, Posner MC, Fung JJ, Agrawal N, Jeevanandam V, Matthews JB.: Medically Necessary, Time-Sensitive Procedures: Scoring System to Ethically and Efficiently Manage Resource Scarcity and Provider Risk During the COVID-19 Pandemic. J Am Coll Surg. 2020 Aug;231(2):281-288. doi: 10.1016/j.jamcollsurg.2020.04.011. Epub 2020 Apr 9.
Hibi T, Rela M, Eason JD, Line PD, Fung J, Sakamoto S, Selzner N, Man K, Ghobrial RM, Sapisochin G.: Liver Transplantation for Colorectal and Neuroendocrine Liver Metastases and Hepatoblastoma. Working Group Report From the ILTS Transplant Oncology Consensus Conference. Transplantation. 2020 Jun;104(6):1131-1135. doi: 10.1097/TP.0000000000003118.
Jayant K, Reccia I, Virdis F, Pyda JS, Bachul PJ, di Sabato D, Barth RN, Fung J, Baker T, Witkowski P. COVID-19 in hospitalized liver transplant recipients: An early systematic review and meta-analysis. Clin Transplant. 2021 Apr;35(4):e14246. doi: 10.1111/ctr.14246. Epub 2021 Feb 25.
Madariaga MLL, Guthmiller JJ, Schrantz S, Jansen MO, Christensen C, Kumar M, Prochaska M, Wool G, Durkin-Celauro A, Oh WH, Trockman L, Vigneswaran J, Keskey R, Shaw DG, Dugan H, Zheng NY, Cobb M, Utset H, Wang J, Stovicek O, Bethel C, Matushek S, Giurcanu M, Beavis KG, di Sabato D, Meltzer D, Ferguson MK, Kress JP, Shanmugarajah K, Matthews JB, Fung JF, Wilson PC, Alverdy JC, Donington JS.: Clinical predictors of donor antibody titre and correlation with recipient antibody response in a COVID-19 convalescent plasma clinical trial. J Intern Med. 2021 Apr;289(4):559-573. doi: 10.1111/joim.13185. Epub 2020 Nov 3.
Cotter TG, Sandıkçı B, Paul S, Gampa A, Wang J, Te H, Pillai A, Reddy KG, di Sabato D, Little EC, Sundaram V, Fung J, Lucey MR, Charlton M.: Liver transplantation for alcoholic hepatitis in the United States: Excellent outcomes with profound temporal and geographic variation in frequency. Am J Transplant. 2021 Mar;21(3):1039-1055. doi: 10.1111/ajt.16143. Epub 2020 Aug 13.
Bachul PJ, Golab K, Basto L, Zangan S, Pyda JS, Perez-Gutierrez A, Borek P, Wang LJ, Tibudan M, Tran DK, Anteby R, Generette GS, Chrzanowski J, Fendler W, Perea L, Jayant K, Lucander A, Thomas C, Philipson L, Millis JM, Fung J, Witkowski P.: Post-Hoc Analysis of a Randomized, Double Blind, Prospective Study at the University of Chicago: Additional Standardizations of Trial Protocol are Needed to Evaluate the Effect of a CXCR1/2 Inhibitor in Islet Allotransplantation. Cell Transplant. 2021 Jan-Dec;30:9636897211001774. doi: 10.1177/09636897211001774.
Chen M, Rosenberg J, Cai X, Hsuan Lee AC, Shi J, Nguyen M, Wignakumar T, Mirle V, Edobor AJ, Fung J, Donington JS, Shanmugarajah K, Lin Y, Chang E, Randall G, Penaloza-MacMaster P, Tian B, Madariaga ML, Huang J.: Nanotraps for the containment and clearance of SARS-CoV-2. Matter. 2021 Apr 22. doi: 10.1016/j.matt.2021.04.005.
Jamil O, Fung J, Kelly D, Azzam R.: Perioperative fatal pulmonary embolism in a pediatric liver transplant recipient. Pediatr Transplant. 2021 Mar 27:e14017. doi: 10.1111/petr.14017. Online ahead of print.
Perez-Gutierrez A, Danz D, Chang A, Sekar P, Cummings R, Bachul PJ, Becker Y, Fung J.: Arterial Intimal Fibrosis in Reperfusion Biopsy Correlates with Graft Function after Kidney Transplant. Nephron. 2021;145(2):150-156. doi: 10.1159/000513120. Epub 2021 Jan 28.
Witkowski P, Philipson LH, Kaufman DB, Ratner LE, Abouljoud MS, Bellin MD, Buse JB, Kandeel F, Stock PG, Mulligan DC, Markmann JF, Kozlowski T, Andreoni KA, Alejandro R, Baidal DA, Hardy MA, Wickrema A, Mirmira RG, Fung J, Becker YT, Josephson MA, Bachul PJ, Pyda JS, Charlton M, Millis JM, Gaglia JL, Stratta RJ, Fridell JA, Niederhaus SV, Forbes RC, Jayant K, Robertson RP, Odorico JS, Levy MF, Harland RC, Abrams PL, Olaitan OK, Kandaswamy R, Wellen JR, Japour AJ, Desai CS, Naziruddin B, Balamurugan AN, Barth RN, Ricordi C; “Islets for US” Collaborative: The demise of islet allotransplantation in the United States: A call for an urgent regulatory update. Am J Transplant. 2021 Apr;21(4):1365-1375. doi: 10.1111/ajt.16397. Epub 2021 Feb 10.
Generette GS, Bachul PJ, Boylan KE, Yassan LJ, Hart J, Pyda JS, Matthews JB, Fung J, Witkowski P.: Neither amyloid depositions nor hepatic steatosis are associated with marginal islet mass early after autotransplantation. Am J Transplant. 2021 May;21(5):1985-1987. doi: 10.1111/ajt.16406. Epub 2021 Jan 2.
Nair A, Coromina Hernandez L, Shah S, Zervos X, Zimmerman M, Sasaki K, Diago T, Hashimoto K, Fujiki M, Aucejo F, Bollinger J, Kaiser TL, Miller CM, Quintini C, Fung JJ, Eghtesad B. Induction Therapy With Antithymocyte Globulin and Delayed Calcineurin Inhibitor Initiation for Renal Protection in Liver Transplantation: A Multicenter Randomized Controlled Phase II-B Trial. Transplantation. 2021 Jul 27. doi: 10.1097/TP.0000000000003904. Epub ahead of print. PMID: 34319926.
Grybowski D, Bachul PJ, Pyda JS, Kijek M, Fillman N, Perez-Gutierrez A, Basto L, Golab K, Wang LJ, Tibudan M, Lucander A, Azzam R, Chrzanowski J, Fendler W, Fung J, Matthews JB, Nagpal S, Witkowski P, Slidell MB. Pain resolution and glucose control in pediatric patients with chronic pancreatitis after total pancreatectomy with islet auto-transplantation. Pediatr Surg Int. 2021 Oct;37(10):1383-1392. doi: 10.1007/s00383-021-04956-5. Epub 2021 Jul 10. PMID: 34245339.
Anteby R, Lucander A, Bachul PJ, Pyda J, Grybowski D, Basto L, Generette GS, Perea L, Golab K, Wang LJ, Tibudan M, Thomas C, Fung J, Witkowski P. Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus. J Clin Med. 2021 Jun 19;10(12):2708. doi: 10.3390/jcm10122708. PMID: 34205321; PMCID: PMC8233942.
Cotter TG, Wang J, Lieber SR, Odenwald MA, Rich NE, Marrero JA, Singal AG, Mitchell MC, Aronsohn A, Charlton M, Fung J. “Raising HOPE”: Improved Outcomes for HIV/HCV-coinfected Liver Transplant Recipients in the Direct-acting Antiviral Era. Transplant Direct. 2021 Jun 8;7(7):e707. doi: 10.1097/TXD.0000000000001154. PMID: 34124343; PMCID: PMC8191686.
Chen M, Rosenberg J, Cai X, Hsuan Lee AC, Shi J, Nguyen M, Wignakumar T, Mirle V, Edobor AJ, Fung J, Donington JS, Shanmugarajah K, Lin Y, Chang E, Randall G, Penaloza-MacMaster P, Tian B, Madariaga ML, Huang J. Nanotraps for the containment and clearance of SARS-CoV-2. Matter. 2021 Jun 2;4(6):2059-2082. doi: 10.1016/j.matt.2021.04.005. Epub 2021 Apr 22. PMID: 33907732; PMCID: PMC8062026.
R. Angelica Perez Gutierrez, MD
Perez-Gutierrez A, Siddiqi U, Kim G, Rangrass G, Kacha A, Jeevanandam V, Potter L, Becker Y, Fung J, Baker T. Best practices for combined heart-liver-kidney transplant: The University of Chicago Medicine experience. Clin Transplant, In press.
Perez-Gutierrez A, Nguyen A, DiSabato D, Baker TB. Left ventricular aneurysm penetrating through the diaphragm with compression of the liver in a patient undergoing heart and liver transplantation. Am J Transplant, In press.
Perez-Gutierrez A, Danz D, Chang A, Sekar P, Cummings R, Becker Y, Fung J. Arterial intimal fibrosis in reperfusion biopsy correlates with graft function after kidney transplant. Nephron 2021; 145(2): 150 – 156.
Ezzelarab MB, Zhang H, Sasaki K, Lu L, Zahorchak AF, Van Der Windt D, Dai H, Perez-Gutierrez A, Bhama JK, Thomson AW. Ex vivo expanded donor alloreactive regulatory T cells loose immunoregulatory, proliferation and anti-apoptotic markers after infusion into ATG lymphodepleted, nonhuman primate heart allograft recipients. Transplantation 2021, 105 (9): 1965-1979.
Piotr Witkowski, MD, PhD
Grybowski D, Bachul PJ, Pyda JS, Kijek M, Fillman N, Parez-Guattierez A, Basto L, Golab K, Wang LJ, Tibudan M, Lucander A, Azzam R, Chrzanowski J, Fendler W, Fung J, Matthews JB, Sajan N, Witkowski P, Slidell MB. Pain resolution and glucose control in pediatric patients with chronic pancreatitis after total pancreatectomy with islet auto-transplantation. Pediatric Surgery International, 2021 June 26, https://doi.org/10.1007/s00383-021-04956-5.
Witkowski P, Martin Wijkstrom M, Bachul PJ, Morgan KA, Levy M, Onaca N, Chaidarun SS, Gardner T, Daffonchio L, Shapiro AMJ, Posselt A, Pier A. Ruffini PA, Bellin MD. Targeting CXCR1/2 in the First Multicenter, Double-Blinded, Randomized Trial in Autologous Islet Transplant Recipients. Am J Surg, 2021, 00, 1-11. DOI: 10.1111/ajt.16695.
Monserrat N. Islet Transplantation in the US – Quo Vadis? An Interview with Camilo Ricordi (CR), Ali Naji (AN), Peter Stock (PS), Piotr Witkowski (PW). Transplant International. 2021, May 29, https://doi.org/10.1111/tri.13931
Anteby R, Lucander A, Bachul PJ, Pyda JS, Grybowski D, Basto L, Generette G, Perea L, Golab K, Wang LJ, Tibudan M, , Borek P, Tibudan M, Thomas C, Fung J, Witkowski P. Evaluating the Prognostic Value of Islet Autoantibody Monitoring in Islet Transplant Recipients with Long-Standing Type 1 Diabetes Mellitus. J Clin Med 2021, 10(12), 2708; https://doi.org/10.3390/jcm10122708 19 Jun 2021
Witkowski P, Odorico J, Pyda JS, Anteby R, Stratta RJ, Schrope BA, Hardy MA , Buse J, Leventhal J, Wanxing C, Hussain S, Niederhaus S, Gaglia J, Desai ChS, Wijkstrom M, Kandeel F, Bachul P, Becker YT, Wang LJ, Robertson RP, Olaitan OK, Kozlowski T, Abrams PL, Josephson MA, Andreoni K, Harland R, Kandaswamy R, Posselt AM, Szot GL, Ricordi C on behalf of the Islets for US Collaborative. Arguments against the Requirement of a Biological License Application for Human Pancreatic Islets: The Position Statement of the Islets for US Collaborative Presented during the FDA Advisory Committee Meeting. J Clin Med. 2021 Jun 29;10(13):2878. doi: 10.3390/jcm10132878.PMID: 34209541
Vasu S, Yang J, Hodges J, Abu-El-Haija M, Adams D, Balamurugan A, Beilman G, Chinnakotla S, Conwell D, Freeman M, Gardner T, Hatipoglu B, Kirchner V, Lara L, Morgan K, NathanJ, Posselt A, Pruett T, Schwarzenberg S, Singh V, Wijkstrom M, Witkowski P, Naziruddin B, Bellin M. Association of Circulating miRNAs with Patient, Disease and Islet Isolation Characteristics in Total Pancreatectomy- Islet Autotransplant Recipients from POST”. Cell Transplantation 2021, Jan-Dec;30:963689721999330. doi: 10.1177/0963689721999330.
Lara LVasu S, Yang J, Hodges J, Abu-El-Haija M, Adams D, Balamurugan A, Beilman G, Chinnakotla S, Conwell D, Freeman M, Gardner T, Hatipoglu B, Kirchner V, , Morgan K, NathanJ, Posselt A, Pruett T, Schwarzenberg S, Singh V, Wijkstrom M, Witkowski P, Naziruddin B, Bellin M. Circulating miRNA in Patients Undergoing Total Pancreatectomy and Islet Autotransplantation. Pancreas 2021 Jan-Dec 2021;30:1-11.doi: 10.1177/0963689721999330.
Witkowski P, Barth RN, Japour AJ, Bachul PJ, Pyda JS, Nowicki E, Ricordi C. on behalf of the “Islet for US Collaborative”. Regulatory updates are needed to prevent commercialization of islet transplantation in the US. Am J Transplant, 2021, March 8, https://doi.org/10.1111/ajt.16555.
Bachul PJ, Gołąb K, Basto L, Zangan S, Pyda J, Perez Gutierrez A, Borek P, Wang LJ, Tibudan M, ,Tran DK, Anteby R, Gennerete GS, Chrzanowski J, Fendler W, Perea L, Jayant K, Lucander A, Thomas C, Philipson L, Millis JM, Fung J, Witkowski P. Post-hoc Analysis of a Randomized, Double Blind, Prospective Study: More Standardizations in the Trial Protocol are Needed to Evaluate the Effect of a CXCR1/2 Blocker in Islet Allotransplantation. Cell Transplant 2021, 30:1-18. doi: 10.1177/09636897211001774.PMID: 33908301
Jayant K, Reccia I, Virdis F, Pyda JS, Di Sabato, Barth R, Fung J, Baker T, Witkowski P. COVID-19 in hospitalized liver transplant recipients: an early systematic review and meta-analysis. Clinical Transplantation, 2021; 00:e14246. https://doi.org/10.1111/ctr.14246.
Desai Ch, Szerpruch KR, Vonderau JS, Chetbourn M, Pattou F, Coats T, De Paep DL, Hawthorne W, Khan KM, de Koning EJP, Naziruddin B, Posselt A, Schrope B, Wijkstrom, Witkowski P, Shapiro J. Anticoagulation Practices in Total Pancreatectomy with Autologous Islet Cell Transplant Patients: An International Survey of Clinical Programs. Transplant International, 2021, 2 Jan 16 doi: 10.1111/tri.13821.
Trikudanathan G, Elmunzer BJ, Yang Y, Abu-El-Haija M, Adams D, Ahmad S, Balamurugan AN, Beilman GJ, Chinnakotla S, Conwell DL, Freeman ML, Gardner TB, Hatipoglu B, Hodges JS, Kirchner V, Lara LF, Long-Simpson L, Mitchell R, Morgan K, Nathan JD, Naziruddin B, Posselt A, Pruett TL, Schwarzenberg SJ, Singh VK, Smith K, Wijkstrom M, Witkowski P, Bellin MD. Preoperative ERCP has no impact on islet yield following total pancreatectomy and islet autotransplantation (TPIAT): Results from the Prospective Observational Study of TPIAT (POST) cohort. Pancreatology. 2021 Jan;21(1):275-281. doi: 10.1016/j.pan.2020.11.008. Epub 2020 Nov 24.PMID: 33323311
Bachul PJ, Gołąb K, Basto L, Borek P, Perea L, Tibudan M, Pyda JS, Perez Gutierrez A, Fung J, Matthews JM, Witkowski P. Long-term stability of beta cell graft function after total pancreatectomy and islet autotransplantation. Pancreas, 2021 Jan 1;50(1):e2-e4. doi: 10.1097/MPA.0000000000001711.
Witkowski P, Philipson L, Kaufman DB, Ratner L, Abouljoud, Bellin M, Buse J, Kandeel F, Stock P, Mulligan D, , Markmann F, Kozlowski T, Andreoni K, Alejandro R, Baidal D, Hardy MA, Wickrema A, Mirmira RG, John Fung J, Becker YT, Josephson MA, Bachul PJ, Pyda JS, Charlton M, Millis JM, Gaglia J, Stratta RJ, Fridell JA, Niederhaus S, Forbes RC, Jayant K, Robertson RP, Odorico J, Levy M, Harland R, Abrams PL, Olaitan OK, Kandaswamy R, Wellen J, Japour AJ, Desai CS, Naziruddin B, Balamurugan AN, Barth RN, Ricordi C. The “Islets for US” Collaborative. The Demise of Islet Allotransplantation in the US: A Call for an Urgent Regulatory Update. Am J Transplant, 2020, Nov 29, doi:10.1111/ajt.16397. Am J Transplant. 2021 Apr;21(4):1365-1375. doi: 10.1111/ajt.16397. Epub 2021 Feb 10.PMID: 33251712 .
Generette G, Bachul PJ, Golab K, Basto L, Pyda JS, Anteby R, Borek P, Tibudan M, Perea L, Charlton M, Perez Guttierez A, Jayant K, Lucander A, Matthews JB, Millis JM, Fung J, Witkowski P. En Bloc Liver and Pancreas Transplantation after Total Pancreatectomy with Autologous Islet Transplantation. Eur J Transl Clin Med 2020 (3), No. 2: 11-17
Generette G, Bachul PJ, Boylan K, Yassan LJ, John Hart J, Pyda JS, Matthews JB, Fung J, Witkowski P. Neither Amyloid Depositions nor Hepatic Steatosis are Associated with Marginal Islet Mass Early After Autotransplantation. Am J Transplant, 2020, Nov 20, doi: 10.1111/ajt.16406
Gołebiewska J, Wolnik B, Hoffmann, Gorycki TM, Sledzinski M, Gołab K, Skowronka P, Milecka A, Skora I, Gulczynski J, Zygowska I, Witkowski P, Moszkowska G, Szurowska E, , Sledzinski Z, Stefaniak T, Debska- Slizien A. Pancreatic islet transplantation in simultaneous pancreas and kidney transplant recipient- a case report. Clinical Diabetology. 2020 9, 1-6.
residents & fellows
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